Doctor with mother and child

OCG Mission

The mission of the NCI’s Office of Cancer Genomics (OCG) is to advance the molecular understanding of cancers with the goal to improve patient outcomes. OCG supports structural, functional, and translational genomic programs, as well as the development of next generation cancer models, to accelerate the translation of findings into the clinic and contribute to precision oncology.


Cancer Genome Characterization Initiative Banner. Links to Program Page

CGCI supports research to comprehensively catalog the genomic alterations in adult and pediatric cancers. The research community can use CGCI data to gain insight into the underlying mechanisms of these cancers and identify potential therapeutic targets.

Banner for CTD squared program. Links to CTD squared program page

CTD2 bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics. It specializes in computational and functional genomics approaches critical for translating next-generation sequencing data, as well as high-throughput and high content small molecule and genetic screens.

Banner for Human Cancer Model Initiative

The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel human tumor-derived culture models, which are annotated with genomic and clinical data. In an effort to advance cancer research and more fully understand how in vitro findings are related to clinical biology, HCMI-developed models and related data will be available as a community resource for cancer research.

Therapeutically Applicable Research To Generate Effective Treatments Program Banner

TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. Investigators form a collaborative network to facilitate discovery of molecular targets and translate those findings into the clinic. TARGET is managed by NCI’s Office of Cancer Genomics and Cancer Therapy Evaluation Program.


The OCG furthers its mission to advance and accelerate genomics science by disseminating the data and resources generated by OCG supported programs to the research community.