What are some of the examples of how other next-generation cancer models have been used?

Answer: 
  • Tuveson D, Clevers H. Cancer modeling meets human organoid technology. Science. 2019;364(6444):952-955. doi:10.1126/science.aaw6985 (PMID: 31171691)
  • Zou Y, Palte MJ, Deik AA, et al. A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis. Nat Commun. 2019;10(1):1617. Published 2019 Apr 8. doi:10.1038/s41467-019-09277-9 (PMID: 30962421)
  • Chan EM, Shibue T, McFarland JM, et al. WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Nature. 2019;568(7753):551-556. doi:10.1038/s41586-019-1102-x (PMID: 30971823)
  • Tiriac H, Plenker D, Baker LA, Tuveson DA. Organoid models for translational pancreatic cancer research. Curr Opin Genet Dev. 2019; 54:7-11. doi:10.1016/j.gde.2019.02.003 (PMID: 30844513)
  • Neal JT, Li X, Zhu J, et al. Organoid Modeling of the Tumor Immune Microenvironment. Cell. 2018;175(7):1972-1988.e16. doi: 10.1016/j.cell.2018.11.021(PMID: 30550791)
  • Tiriac H, Belleau P, Engle DD, et al. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer. Cancer Discov. 2018;8(9):1112-1129. doi:10.1158/2159-8290.CD-18-0349 (PMID: 29853643)
  • Li X, Francies HE, Secrier M, et al. Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics. Nat Commun. 2018;9(1):2983. Published 2018 Jul 30. doi:10.1038/s41467-018-05190-9 (PMID: 30061675)
  • Buczacki SJA, Popova S, Biggs E, et al. Itraconazole targets cell cycle heterogeneity in colorectal cancer. J Exp Med. 2018;215(7):1891-1912. doi:10.1084/jem.20171385 (PMID: 29853607)
  • Sachs N, de Ligt J, Kopper O, et al. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. Cell. 2018 Jan 11;172(1-2):373-386. (PMID: 29224780)
  • Weeber F, Ooft SN, Dijkstra KK, Voest EE. Tumor Organoids as a Pre-clinical Cancer Model for Drug Discovery. Cell Chem Biol. 2017;24(9):1092-1100. doi:10.1016/j.chembiol.2017.06.012 (PMID: 28757181)
  • Boj SF, Hwang CI, Baker LA, et al. Organoid models of human and mouse ductal pancreatic cancer. Cell. 2015 Jan 15;160(1-2):324-38. (PMID: 25557080)
  • Baker LA, Tiriac H, Clevers H, Tuveson DA. Modeling pancreatic cancer with organoids. Trends in Cancer. 2016 Apr;2(4):176-190. (PMID: 27135056)
Associated Program: 
Human Cancer Models Initiative
PGDI: 
No
FAQ Category: 
Last updated: July 22, 2020