Glossary Terms

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Partial Response

A decrease in the size of a tumor, or in the extent of cancer in the body, in response to treatment. Also called partial remission.


A modality designed to disrupt a specific intracellular process (or processes), thereby providing information about the operation of pathways/networks within a cancer cell. Perturbagens may be chemical compounds (small molecules), or biologicals (antibodies, proteins), or multi-component tools (e.g., CRISPR genome modulators). Perturbagens may also serve as prototypes for therapeutic modalities.

Point Mutation

Change of a single nucleotide.


A common variation in the sequence of DNA among individuals.

Progressive Disease

Cancer that is growing, spreading, or getting worse.