News & Publications

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Dai et al. (2021) Cell Rep. CC BY-NC-ND 4.0
Cell Reports

Metastasis is a complex and poorly understood process. In pancreatic cancer, loss of the transforming growth factor (TGF)-β/BMP effector SMAD4 is correlated with changes in altered histopathological transitions, metastatic disease, and poor prognosis. In this study, we use isogenic cancer cell...

Mohanty et al. (2021) Cell Reports Medicine. CC BY-NC-ND 4.0
Cell Reports Medicine

Uncoupling of mRNA expression from copy number (UECN) might be a strategy for cancer cells to a tolerate high degree of aneuploidy. To test the extent and role of UECN across cancers, we perform integrative multiomic analysis of The Cancer Genome Atlas (TCGA) dataset, encompassing ∼5,000...


Issue 25, February, 2021

CTD² Program Highlights

Cancer Target Discovery and Development Logo
Kenneth Smith, Ph.D., Vlado Dancik, Ph.D., Zhou Ji, Ph.D., Aristidis Floratos, Ph.D., and Paul Clemons, Ph.D.
Last updated: July 30, 2021