News & Publications

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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

All Programs

Office of Cancer Genomics launches new program

July 11, 2016

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Genomic Data Commons

June 06, 2016

Publications

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CTD²

Myoepithelial cells are a dynamic barrier to epithelial dissemination.

Journal of Cell Biology.

The mammary epithelium is composed of an inner luminal and surrounding myoepithelial cell layer. The presence of cancer cells beyond the myoepithelium defines invasive breast cancer, yet the role of the myoepithelium during invasion remains unclear. We developed a 3D organotypic culture assay to...

TP53 Mutation Landscape from the Genomic Data Commons

CTD²

Mutational processes shape the landscape of TP53 mutations in human cancer.

Nature Genetics

Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations^1,2. Mutant p53 protein is often abundantly expressed in cancers and specific allelic variants exhibit dominant-negative or gain-of-function activities in...

Last updated: October 10, 2018