News & Publications

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Surgery, Breast-Conserving, Female
Cancer Research

Dissemination is an essential early step in metastasis but its molecular basis remains incompletely understood. To define the essential targetable effectors of this process, we developed a 3D mammary epithelial culture model, in which dissemination is induced by overexpression of the...

Proposed model of ST-mediated transformation

Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of human cancers and partial loss of PP2A function contributes to cell transformation. Displacement of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alters the...


Issue 23, December, 2019

Featured Researchers

Headshot of Dr. Andy Mungall
Interviewed by Cindy Kyi, Ph.D.
Last updated: January 24, 2020