Gastrointestinal stromal tumor (GIST) is commonly driven by oncogenic KIT mutations that are effectively targeted by imatinib (IM), a tyrosine kinase inhibitor (TKI). However, IM does not cure GIST, and adjuvant therapy only delays recurrence in high-risk tumors. We hypothesized that GIST...
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CTD²
Molecular Cancer Therapeutics
CTD²
STAR Protocols
Protein-protein interactions (PPIs) have emerged as promising yet challenging therapeutic targets. A robust bioassay is required for rapid PPI modulator discovery. Here, we present a time-resolved Förster's (fluorescence) resonance energy transfer assay protocol for PPI modulator screening in a...
e-Newsletter
Issue 25, February, 2021
HCMI Program Highlights
Eva Tonsing-Carter, Ph.D. and Cindy Kyi, Ph.D.
Last updated: November 07, 2021