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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

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Office of Cancer Genomics launches new program

July 11, 2016

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Genomic Data Commons

June 06, 2016

Publications

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Diagram showing cancer cells spreading into the blood stream CRUK 448

CTD²

A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies.

Science

TP53, which encodes the tumor suppressor p53, is the most frequently mutated gene in human cancer. The selective pressures shaping its mutational spectrum, dominated by missense mutations, are enigmatic, and neomorphic gain-of-function (GOF) activities have been implicated. We used CRISPR-Cas9...

Summary hypothesis of the effects of SOX4 on WNT5a and invasion.

CTD²

SOX4 regulates invasion of bladder cancer cells via repression of WNT5a.

International Journal of Oncology

Sry‑Related HMG‑BOX‑4 (SOX4) is a developmental transcription factor that is overexpressed in as many as 23% of bladder cancer patients; however, the role of SOX4 in bladder cancer tumorigenesis is not yet well understood. Given the many roles of SOX4 in embryonic development and the context‑...

Last updated: August 15, 2019