News & Publications

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Publications

KRAS Protein Structure
CTD²
Cold Spring Harbor Perspectives in Medicine

KRAS is the most commonly mutated oncogene in human cancer. Most KRAS-mutant cancers depend on sustained expression and signaling of KRAS, thus making it a high-priority therapeutic target. Unfortunately, development of direct small molecule inhibitors of KRAS function has been challenging. An...

Breast Cancer Stage IIIB
CTD²
eLife

Alternative splicing of mRNA precursors represents a key gene expression regulatory step and permits the generation of distinct protein products with diverse functions. In a genome-scale expression screen for inducers of the epithelial-to-mesenchymal transition (EMT), we found a striking...

Last updated: May 15, 2013