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Publications

Malate-Aspartate shuttle
CTD²
Proc Natl Acad Sci

Oncogenic PIK3CA mutations are found in a significant fraction of human cancers, but therapeutic inhibition of PI3K has only shown limited success in clinical trials. To understand how mutant PIK3CA contributes to cancer cell proliferation, we used genome scale loss-of-function...

CAT scan image of GBM
All Programs
Oncogene

Glioblastoma (GBM) is the most common primary brain tumor and has a dismal prognosis. Amplification of chromosome 12q13-q15 (Cyclin-dependent kinase 4 (CDK4) amplicon) is frequently observed in numerous human cancers including GBM. Phosphoinositide 3-kinase enhancer (PIKE) is a group of GTP-...

e-Newsletter

Issue 15, October, 2016

OCG Perspective

Nadia Jaber
Last updated: May 15, 2013