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Publications

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Proposed working model: p85α in the PI3K heterodimeric complex stabilizes but inhibits p110, whereas p110-free 85α molecules form homodimers to stabilize PTEN.
CTD²

Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer.

Nature Communications

Copy number loss of PIK3R1 (p85α) most commonly occurs in ovarian cancer among all cancer types. Here we report that ovarian cancer cells manifest a spectrum of tumorigenic phenotypes upon knockdown of PIK3R1. PIK3R1 loss activates AKT and p110-independent JAK2/STAT3 signaling through inducing...

Lung Cancer, Non-Small Cell, Stage IIIB
CTD²

Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins.

Cancer Research

Chromosomal rearrangements involving receptor tyrosine kinases (RTK) are a clinically relevant oncogenic mechanism in human cancers. These chimeric oncoproteins often contain the C-terminal kinase domain of the RTK joined in cis to various N-terminal, nonkinase fusion partners. The functional...

e-Newsletter

Issue 20, November, 2018

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TARGET Program Highlight

Thomas B. Alexander, MD, MPH and Charles G. Mullighan, MBBS (Hons), MSc, MD

Genomic Discoveries in Pediatric Mixed Phenotype Acute Leukemia Inform Therapeutic Approaches

Thomas B. Alexander, MD, MPH and Charles G. Mullighan, MBBS (Hons), MSc, MD
Last updated: February 19, 2019

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