News & Publications

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Publications

Copyright © 2021 Elsevier B.V.
CTD²
Cell

Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 master regulator (MR) proteins responsible for canalizing the genetics of...

Copyright © 2020 Elsevier B.V.
CTD²
Cell Reports

Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosomal sorting complexes required for transport (ESCRT)...

e-Newsletter

Issue 24, August, 2020

HCMI Program Highlights

Banner for Human Cancer Model Initiative
Eva Tonsing-Carter, Ph.D. and Cindy Kyi, Ph.D.
Last updated: January 16, 2021