News & Publications

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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

All Programs

Office of Cancer Genomics launches new program

July 11, 2016

All Programs

Genomic Data Commons

June 06, 2016

Publications

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CTD²

Large tumor suppressor 2, LATS2, activates JNK in a kinase-independent mechanism through ASK1.

Journal of Molecular Cell Biology

Apoptosis signal-regulating kinase 1 (ASK1) is an important mediator of the cell stress response pathways. Because of its central role in regulating cell death, the activity of ASK1 is tightly regulated by protein-protein interactions and post-translational modifications. Deregulation of ASK1...

CTD²

Integration of Tumor Genomic Data with Cell Lines Using Multi-dimensional Network Modules Improves Cancer Pharmacogenomics.

Cell Systems

Leveraging insights from genomic studies of patient tumors is limited by the discordance between these tumors and the cell line models used for functional studies. We integrate omics datasets using functional networks to identify gene modules reflecting variation between tumors and show that the...

Last updated: December 04, 2018