News & Publications

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Publications

Breast Cancer Stage IIIB
CTD²
Journal of Cell Biology.

The mammary epithelium is composed of an inner luminal and surrounding myoepithelial cell layer. The presence of cancer cells beyond the myoepithelium defines invasive breast cancer, yet the role of the myoepithelium during invasion remains unclear. We developed a 3D organotypic culture assay to...

TP53 Mutation Landscape from the Genomic Data Commons
CTD²
Nature Genetics

Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein p53 (TP53) are missense mutations1,2. Mutant p53 protein is often abundantly expressed in cancers and specific allelic variants exhibit dominant-negative or gain-of-function activities in...

Last updated: October 10, 2018