News & Publications

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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

HCMI

Office of Cancer Genomics launches new program

July 11, 2016

All Programs

Genomic Data Commons

June 06, 2016

Publications

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CTD²

Targeting BET proteins BRD2 and BRD3 in combination with PI3K-AKT inhibition as a therapeutic strategy for ovarian clear cell carcinoma

Molecular Cancer Therapeutics

Ovarian clear cell carcinoma (OCCC) is a rare, chemo-resistant subtype of ovarian cancer. To identify novel therapeutic targets and combination therapies for OCCC, we subjected a set of patient-derived ovarian cancer cell lines to arrayed high throughput siRNA and drug screening. The results...

DNA methylation patterns are stable at relapse except in a minority of cases.

CTD²

DNA methylation epitypes highlight underlying developmental and disease pathways in acute myeloid leukemia

Genome Research

Acute myeloid leukemia (AML) is a molecularly complex disease characterized by heterogeneous tumor genetic profiles and involving numerous pathogenic mechanisms and pathways. Integration of molecular data types across multiple patient cohorts may advance current genetic approaches for improved...

Last updated: April 13, 2021