News & Publications

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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

HCMI

Office of Cancer Genomics launches new program

July 11, 2016

All Programs

Genomic Data Commons

June 06, 2016

Publications

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CTD²

A modular master regulator landscape controls cancer transcriptional identity

Cell

Despite considerable efforts, the mechanisms linking genomic alterations to the transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a network-based approach, identified 407 master regulator (MR) proteins responsible for canalizing the genetics of...

CTD²

Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q

Cell Reports

Few therapies target the loss of tumor suppressor genes in cancer. We examine CRISPR-SpCas9 and RNA-interference loss-of-function screens to identify new therapeutic targets associated with genomic loss of tumor suppressor genes. The endosomal sorting complexes required for transport (ESCRT)...

Last updated: January 16, 2021