News & Publications

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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

All Programs

Office of Cancer Genomics launches new program

July 11, 2016

All Programs

Genomic Data Commons

June 06, 2016

Publications

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Scheme summarizing the molecular network driving the intrinsic GPX4 dependency and ferroptosis susceptibility in clear-cell carcinomas

CTD²

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.

Nature Communications

Clear-cell carcinomas (CCCs) are a histological group of highly aggressive malignancies commonly originating in the kidney and ovary. CCCs are distinguished by aberrant lipid and glycogen accumulation and are refractory to a broad range of anti-cancer therapies. Here we identify an intrinsic...

CTD²

Dampening oncogenic RAS signaling.

Science

Last updated: April 16, 2019