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TARGET

Working Towards Greater Precision in Childhood Cancers

March 07, 2018

All Programs

Office of Cancer Genomics launches new program

July 11, 2016

All Programs

Genomic Data Commons

June 06, 2016

Publications

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Graphical abstract from Chun, et al (2019).

TARGET

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.

Cell Reports

Extra-cranial malignant rhabdoid tumors (MRTs) and cranial atypical teratoid RTs (ATRTs) are heterogeneous pediatric cancers driven primarily by SMARCB1 loss. To understand the genome-wide molecular relationships between MRTs and ATRTs, we analyze multi-omics data from 140 MRTs and 161 ATRTs. We...

The RET, RAS-RAF-MAPK pathway with sites of RXDX-105 inhibition in red.

CTD²

The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo.

Oncotarget

Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of the RET kinase and the RAS-MAPK pathway have previously...

Last updated: December 10, 2019