Plasticity of the cell state has been proposed to drive resistance to multiple classes of cancer therapies, thereby limiting their effectiveness. A high-mesenchymal cell state observed in human tumors and cancer cell lines has been associated with resistance to multiple treatment modalities...
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TARGET
Nature Genetics
Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts has not been carried out....
e-Newsletter
Issue 16, July, 2017
CTD² Program Highlight
Subhashini Jagu, Ph.D. and Daniela S. Gerhard, Ph.D.
Last updated: May 15, 2013