The Cancer Dependency Map enables drug mechanism-of-action investigations.

By profiling hundreds of patient models of human cancer, the Cancer Dependency Map systematically identifies gene dependencies, small molecule sensitivities, and the markers that predict their response

Vazquez et al. (2020) Mol Syst Biol. CC BY 4.0

Vazquez F, Boehm JS.

Mol Syst Biol.

July 01, 2020

How do small molecules exert their effects in mammalian cells? This seemingly simple question continues to represent one of the fundamental challenges of modern translational science and as such has long been the subject of intense scientific scrutiny. In their recent study, Garnett and colleagues (Gonçalves et al, 2020) demonstrate proof-of-concept for a new way to attack this problem systematically for Oncology drugs, by identifying correlated CRISPR- and drug-killing profiles in the Cancer Dependency Map dataset.

Last updated: August 20, 2020