Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Genome-scale open reading frame screen identifies RNA binding proteins, QK1 and RBFOX1, regulate the alternate splicing of actin binding protein, FLNB. The skipping of FLNB exon 30 is associated with the transition to mesenchymal- and stem-like cell states in breast cancer pathogenesis.
Scientists at DFCI demonstrated that binding of transcription factor, ERG, to chromatin remodeling complex, BAF, is essential to facilitate basal-to-luminal transition, a hallmark of prostate oncogenesis.
Researchers at UCSF developed an analytical framework for constructing a human genetic interaction map, a powerful tool to identify genetic interactions between genes and suggest new combination therapies for cancer.
In vivo gain-of-function genetic screen identifies TMEMB, a transmembrane protein as a novel driver of invasion and metastasis in lung cancer.
In vivo functional screening identifies transcriptional repressor, GATAD2B, as a potent driver of tumor growth and metastasis in KRAS-mutant lung cancer through interaction with c-Myc.