Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

TARGET
September 15, 2011
Blood

In the largest pediatric cancer genome sequencing effort reported to date, TARGET ALL researchers sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias (HR B-ALL).

CGCI
July 27, 2011
Nature

Morin et al. uncovered a novel role for chromatin modification in driving the progression of two non-Hodgkin lymphomas (NHLs), follicular lymphoma and diffuse large B-cell lymphoma.

CTD²
July 26, 2011
Proceedings of the National Academy of Sciences

A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches.

CTD²
July 13, 2011
Nature

The authors introduce a small molecule to induce apoptosis selectively in cancer cells.

CTD²
April 08, 2011
Genes and Development

High-throughput tools for nucleic acid characterization now provide the means to conduct comprehensive analyses of all somatic alterations in the cancer genomes.

CTD²
March 08, 2011
Cancer Cell

The authors screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on 11q13.3, FGF19.

TARGET
March 01, 2011
Nature Genetics

In a letter published in Nature Genetics, pediatric researchers found that Native American ancestry is genetically linked with an increased risk of relapse in childhood acute lymphoblastic leukemia (ALL), the most common cancer in children.

CGCI
January 28, 2011
Science

Through whole exome sequencing, researchers found that pediatric medulloblastoma, the most common malignant brain tumor found in children, contained a fraction of the mutations found in adult cancers and suggested dysregulation of developmental pathways as a mechanism underlying medulloblastomas.

TARGET
December 02, 2010
Blood

Through unsupervised clustering of gene expression profiling, TARGET researchers discovered eight unique cluster groups among patients with pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL). 

CTD²
September 01, 2010
Nature Biotechnology

Genomic analysis of primary tumors is providing extraordinary insights into the molecular changes in genes and pathways that cause cancer.

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