Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
In the largest pediatric cancer genome sequencing effort reported to date, TARGET ALL researchers sequenced 120 candidate genes in 187 high-risk childhood B-precursor acute lymphoblastic leukemias (HR B-ALL).
Morin et al. uncovered a novel role for chromatin modification in driving the progression of two non-Hodgkin lymphomas (NHLs), follicular lymphoma and diffuse large B-cell lymphoma.
A comprehensive understanding of the molecular vulnerabilities of every type of cancer will provide a powerful roadmap to guide therapeutic approaches.
The authors introduce a small molecule to induce apoptosis selectively in cancer cells.
High-throughput tools for nucleic acid characterization now provide the means to conduct comprehensive analyses of all somatic alterations in the cancer genomes.
The authors screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on 11q13.3, FGF19.
In a letter published in Nature Genetics, pediatric researchers found that Native American ancestry is genetically linked with an increased risk of relapse in childhood acute lymphoblastic leukemia (ALL), the most common cancer in children.
Through whole exome sequencing, researchers found that pediatric medulloblastoma, the most common malignant brain tumor found in children, contained a fraction of the mutations found in adult cancers and suggested dysregulation of developmental pathways as a mechanism underlying medulloblastomas.
Through unsupervised clustering of gene expression profiling, TARGET researchers discovered eight unique cluster groups among patients with pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL).