Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Researchers find that autocrine IL6 secretion may contribute to MAPK inhibitor resistance in BRAF-mutant cells.
The authors developed a method to grow lung cancer cells in a 4D model which enables the isolation of circulating tumor cells that are responsible for metastasis and analysis in comparison to 2D culture cells.
The authors used a functional kinomics approach to identify novel survival kinases involved in G2-M cell-cycle checkpoint, SFK, PI3K, and FAK pathways in head and neck squamous cell carcinoma.
By screening a custom library of shRNAs directed toward known drug targets in a genetically defined Myc-driven HCC model, researchers identified cyclin-dependent kinase 9 (Cdk9) as required for disease maintenance of hepatocellular carcinoma.
A review of a recent finding connecting the genes GF1 and GF1B in medulloblastoma.
Researchers develop protocol to construct genetic interaction map through two-stage approach.
The authors performed an integrative analysis on 3,527 specimens from 12 cancer types, revealing a unified classification into 11 major subtypes.
In this review researchers describe basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a stochastic "go or grow" model of tumor cell behavior.
Researchers discuss the emerging themes of CAF biology in the context of tumorigenesis and therapy.
The results suggest RAC1 P29S status may offer a predictive biomarker for RAF inhibitor resistance in melanoma patients.
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