Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Cross-species computational analysis of interactomes from mouse models and human prostate cancer identified FOXM1 and CENPF as synergystic master regulators of prostate malignancy/tumor growth.
Using a high-coverage genome-wide shRNA library, researchers identify the characterized protein TMEM129 and the ubiquitin-conjugated E2 enzyme UBE2J2 to be essential for US11-mediated HLA class I downregulation.
Researchers describe toxicity of three new acylated arylamine derivatives (1-3), carpatamides A-C against non-small-cell lung cancer cell lines HCC366, A549, and HCC44.
Researchers show that squamous cell carcinoma antigens 1 and 2 (SCCA1/2), members of the Serpin family of serine/cysteine protease inhibitors, are transcriptionally upregulated by oncogenic Ras via MAPK and the ETS family transcription factor PEA3.
A web-based tool for exploring genomic vulnerabilities in cancer is available at https://cbio.mskcc.org/cancergenomics/statius/.
In this publication, the authors describe the generation of two mouse strains that enable Cre-dependent, robust expression of reverse tet-transactivator 3, providing tissue-restricted and consistent induction of TRE-controlled transgenes.
Researchers discuss identify somatic mutations with archival formalin fixed and paraffin embedded tissue from gallbladder cancer.
This work identifies nuclear PRAS40 as a dual-input signaling checkpoint that links cell growth and proliferation to inhibition of cellular senescence.
This manuscript presents a method called Evaluation of Dependency DifferentialitY (EDDY), which is a statistical test for differential dependencies of a set of genes between two conditions.
Researchers at Emory disucss their high throughput research platforms and efforts to advance understanding of disease-related biology with its HTS/HCS platforms and chemical tools, in support of drug discovery.