Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

CTD²
May 12, 2014
Cancer Cell

Cross-species computational analysis of interactomes from mouse models and human prostate cancer identified FOXM1 and CENPF as synergystic master regulators of prostate malignancy/tumor growth.

CTD²
May 08, 2014
Nature Communcations

Using a high-coverage genome-wide shRNA library, researchers identify the characterized protein TMEM129 and the ubiquitin-conjugated E2 enzyme UBE2J2 to be essential for US11-mediated HLA class I downregulation.

CTD²
April 23, 2014
Journal of Natural Products

Researchers describe toxicity of three new acylated arylamine derivatives (1-3), carpatamides A-C against non-small-cell lung cancer cell lines HCC366, A549, and HCC44.

CTD²
April 23, 2014
Nature Communications

Researchers show that squamous cell carcinoma antigens 1 and 2 (SCCA1/2), members of the Serpin family of serine/cysteine protease inhibitors, are transcriptionally upregulated by oncogenic Ras via MAPK and the ETS family transcription factor PEA3.

CTD²
April 17, 2014
Bioinformatics

A web-based tool for exploring genomic vulnerabilities in cancer is available at https://cbio.mskcc.org/cancergenomics/statius/.

CTD²
April 16, 2014
PLoS One

In this publication, the authors describe the generation of two mouse strains that enable Cre-dependent, robust expression of  reverse tet-transactivator 3, providing tissue-restricted and consistent induction of TRE-controlled transgenes.

CTD²
April 14, 2014
Human Pathology

Researchers discuss identify somatic mutations with archival formalin fixed and paraffin embedded tissue from gallbladder cancer.

CTD²
April 07, 2014
Oncogene

This work identifies nuclear PRAS40 as a dual-input signaling checkpoint that links cell growth and proliferation to inhibition of cellular senescence. 

CTD²
April 01, 2014
Nucleic Acids Research

This manuscript presents a method called Evaluation of Dependency DifferentialitY (EDDY), which is a statistical test for differential dependencies of a set of genes between two conditions.

CTD²
March 13, 2014
Comb Chem High Throughput Screen

Researchers at Emory disucss their high throughput research platforms and efforts to advance understanding of disease-related biology with its HTS/HCS platforms and chemical tools, in support of  drug discovery.

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