Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
A review of how a systems biology approach to cancer research can effect therapy development.
Researchers screen for synthetic lethal interactions with MYC to identify possible routes for therapy.
Researchers identify ARID1A-mutant cancer cells are dependent on ARID1B for survival, suggesting a potential therapeutic target.
Investigators used a novel mouse model to study genetic changes in prostate cancer.
The authors performed an image-based screen for genes regulating glioblastoma tumor-initiating cell maintenance and identified the transcription factor, ZFHX4, as a master regulator.
The researchers identified the GRB2-associated binding protein 2 (GAB2) as a recurrently amplified gene that potently transforms immortalized ovarian and fallopian tube secretory epithelial cells.
Glutathione peroxidase 4 regulates ferroptotic cancer cell death.
Investigators identified molecular players in response and resistance to combination chemotherapy and antiangiogenic drugs.
Residual complexes containing SMARCA2 (BRM) underlie the oncogenic drive of SMARCA4 (BRG1) mutation.
Researchers discuss a role for SMARCA2 in oncogenesis caused by SMARCA4 loss and identify the ATPase and bromodomain-containing SMARCA2 as a potential therapeutic target in these cancers.
Researchers discuss quantitative solution to overcorrection and guidance for effective designs of deep sequencing platforms that facilitate accurate estimation of variant allele fraction and copy number variation.
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