Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

CTD²
May 28, 2014
Nature Medicine

Colon organoid culture functionally validated the microRNA miR-483 as a dominant driver oncogene at the IGF2 (insulin-like growth factor-2) 11p15.5 CRC amplicon, inducing dysplasia in vitro and tumorigenicity in vivo

CTD²
May 20, 2014
Proceedings of the National Academy of Sciences in the United State of America

Investigators show that knockdown or deletion of Hipk2 in vitro and in vivo inhibits white adipose development and negatively affects metabolism.

CTD²
May 12, 2014
Cancer Cell

Cross-species computational analysis of interactomes from mouse models and human prostate cancer identified FOXM1 and CENPF as synergystic master regulators of prostate malignancy/tumor growth.

CTD²
May 08, 2014
Nature Communcations

Using a high-coverage genome-wide shRNA library, researchers identify the characterized protein TMEM129 and the ubiquitin-conjugated E2 enzyme UBE2J2 to be essential for US11-mediated HLA class I downregulation.

CTD²
April 23, 2014
Journal of Natural Products

Researchers describe toxicity of three new acylated arylamine derivatives (1-3), carpatamides A-C against non-small-cell lung cancer cell lines HCC366, A549, and HCC44.

CTD²
April 23, 2014
Nature Communications

Researchers show that squamous cell carcinoma antigens 1 and 2 (SCCA1/2), members of the Serpin family of serine/cysteine protease inhibitors, are transcriptionally upregulated by oncogenic Ras via MAPK and the ETS family transcription factor PEA3.

CTD²
April 17, 2014
Bioinformatics

A web-based tool for exploring genomic vulnerabilities in cancer is available at https://cbio.mskcc.org/cancergenomics/statius/.

CTD²
April 16, 2014
PLoS One

In this publication, the authors describe the generation of two mouse strains that enable Cre-dependent, robust expression of  reverse tet-transactivator 3, providing tissue-restricted and consistent induction of TRE-controlled transgenes.

CTD²
April 14, 2014
Human Pathology

Researchers discuss identify somatic mutations with archival formalin fixed and paraffin embedded tissue from gallbladder cancer.

CTD²
April 07, 2014
Oncogene

This work identifies nuclear PRAS40 as a dual-input signaling checkpoint that links cell growth and proliferation to inhibition of cellular senescence. 

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