Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
The genetically engineeded mouse model system created by the authors produces a disease that recapitulates the progression of pancreatic cancer in human patients and enables the study of the impact of gene perturbation at any stage of pancreas cancer progression.
Researchers describe recent structural and functional studies describing genomic alterations and new regulators of β-catenin that lead to aberrant activation of the WNT/β-catenin pathway.
Researchers use an EGFP-tagged Cas9 protein to image genomic loci and study chromatin dynamics
The authors identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T cell acute lymphoblastic leukemia (T-ALL).
This review discusses important therapeutic targets and provides renewed interest in strategies for the early detection and prevention of childhood cancer.
The authors use an elastic-net regression method on the combined genomic data to identify genetic aberrations and their associated cancer genes that are indicators of clinical stage colorectal cancer.
The results suggest JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, decreasing medulloblastoma cell viability.
Investigators used whole genome sequencing to evaluate the intratumor heterogeneity of one HPV-positive oropharyngeal squamous cell carcinoma.
Researchers identify a specific dependency on BRCA1 and members of the ubiquitin pathway in cyclin E1 amplified tumors and propose a unique therapeutic strategy with bortezomib.