Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

CTD²
January 01, 2014
Genes and Development

The genetically engineeded mouse model system created by the authors produces a disease that recapitulates the progression of pancreatic cancer in human patients and enables the study of the impact of gene perturbation at any stage of pancreas cancer progression.

CTD²
December 20, 2013
Trends in Pharmacological Science

Researchers describe recent structural and functional studies describing genomic alterations and new regulators of β-catenin that lead to aberrant activation of the WNT/β-catenin pathway.

CTD²
December 19, 2013
Cell

Researchers use an EGFP-tagged Cas9 protein to image genomic loci and study chromatin dynamics

CTD²
December 09, 2013
Cancer Cell

The authors identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T cell acute lymphoblastic leukemia (T-ALL). 

CTD²
December 06, 2013
Nature Reviews Cancer

This review discusses important therapeutic targets and provides renewed interest in strategies for the early detection and prevention of childhood cancer.

CTD²
December 05, 2013
BMC Medical Genomics

The authors use an elastic-net regression method on the combined genomic data to identify genetic aberrations and their associated cancer genes that are indicators of clinical stage colorectal cancer.

CTD²
December 02, 2013
Clinical Cancer Research

The results suggest JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, decreasing medulloblastoma cell viability.

CTD²
December 01, 2013
Neoplasia

Investigators used whole genome sequencing to evaluate the intratumor heterogeneity of one HPV-positive oropharyngeal squamous cell carcinoma.

CTD²
November 26, 2013
PNAS

Researchers identify a specific dependency on BRCA1 and members of the ubiquitin pathway in cyclin E1 amplified tumors and propose a unique therapeutic strategy with bortezomib.

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