Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

CTD²
January 02, 2014
Bioinformatics

Researchers discuss quantitative solution to overcorrection and guidance for effective designs of deep sequencing platforms that facilitate accurate estimation of variant allele fraction and copy number variation.

CTD²
January 01, 2014
Genes and Development

The genetically engineeded mouse model system created by the authors produces a disease that recapitulates the progression of pancreatic cancer in human patients and enables the study of the impact of gene perturbation at any stage of pancreas cancer progression.

CTD²
December 20, 2013
Trends in Pharmacological Science

Researchers describe recent structural and functional studies describing genomic alterations and new regulators of β-catenin that lead to aberrant activation of the WNT/β-catenin pathway.

CTD²
December 19, 2013
Cell

Researchers use an EGFP-tagged Cas9 protein to image genomic loci and study chromatin dynamics

CTD²
December 09, 2013
Cancer Cell

The authors identify the AKT1 kinase as a major negative regulator of the NR3C1 glucocorticoid receptor protein activity driving glucocorticoid resistance in T cell acute lymphoblastic leukemia (T-ALL). 

CTD²
December 06, 2013
Nature Reviews Cancer

This review discusses important therapeutic targets and provides renewed interest in strategies for the early detection and prevention of childhood cancer.

CTD²
December 05, 2013
BMC Medical Genomics

The authors use an elastic-net regression method on the combined genomic data to identify genetic aberrations and their associated cancer genes that are indicators of clinical stage colorectal cancer.

CTD²
December 02, 2013
Clinical Cancer Research

The results suggest JQ1 suppresses MYC expression and MYC-associated transcriptional activity in medulloblastomas, decreasing medulloblastoma cell viability.

CTD²
December 01, 2013
Neoplasia

Investigators used whole genome sequencing to evaluate the intratumor heterogeneity of one HPV-positive oropharyngeal squamous cell carcinoma.

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