Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

CTD²
November 21, 2013
Chemistry & Biology

Researchers identify STF-118804 as a specific inhibitor of nicotinamide phosphoribosyl transferase (NAMPT), which improves survival in high-risk acute lymphoblastic leukemia, and targets leukemia stem cells.

CTD²
November 20, 2013
PLoS One

Researchers evaluate xenografts established in NOD/scid/IL2Rγ-null mice from the primary and metastatic tumors of 27 patients with colorectal cancer (CRC) to  assess how faithfully they recapitulated the transcriptional profile of their parental tumors.

CTD²
November 13, 2013
BMC Pharmacology & Toxicology

Researchers demonstrate that transient inhibition of eIF4E protects against cyclophosphamide-induced alopecia at the organismal level.

CTD²
November 07, 2013
Acta Neuropathologica

The results provide novel insights into the synthetic lethal nature of α5-GABAA receptor activation in MYC-driven/Group 3 medulloblastomas and propose targeting it as a novel strategy.

CTD²
October 24, 2013
Cell

We have applied parallel screening of chemical and genetic perturbations within a panel of molecularly annotated non-small-cell lung cancer lines to identify intervention opportunities tightly linked to molecular response indicators predictive of target sensitivity. 

CTD²
October 23, 2013
PLoS One

Researchers present a cancer driver annotation (CanDrA) tool that predicts missense driver mutations based on a set of 95 structural and evolutionary features computed by over 10 functional prediction algorithms.

CTD²
October 15, 2013
Cancer Research

Investigators use a high-throughput assay to identify genomic predictors of radiation sensitivity

CTD²
October 15, 2013
Science Signaling

Researchers accrued a library of natural products and performed a screen to identify molecular targets.

CTD²
October 14, 2013
Cancer Cell

Researchers document coexpression of EGFR and EGFRvIII in primary human glioblastoma that drives transformation and tumorigenesis in a cell-intrinsic manner and clarify specific oncogenic signaling relationships in glioblastoma.

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