Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Researchers at UCSF developed an analytical framework for constructing a human genetic interaction map, a powerful tool to identify genetic interactions between genes and suggest new combination therapies for cancer.
In vivo gain-of-function genetic screen identifies TMEMB, a transmembrane protein as a novel driver of invasion and metastasis in lung cancer.
In vivo functional screening identifies transcriptional repressor, GATAD2B, as a potent driver of tumor growth and metastasis in KRAS-mutant lung cancer through interaction with c-Myc.
Integration of comprehensive molecular characterization and functional genomic studies identifies paralog gene dependencies induced by somatic mutations. Paralog pair, MAGOH and MAGOHB, identified as members of the exon-junction complex was shared between the shRNA and CRISPR datasets.
Natural killer cells derived from human-induced pluripotent stem cells are effective against ovarian cancer in a mouse xenograft model and may provide an off-the-shelf resource for anti-cancer immunotherapy.