Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
This study on Acute myeloid leukemia (AML) indicates that transcriptome sequencing is useful for biomarker discovery, as exemplified by the identification of ITGA5 -E2/3 splice variant as potential novel adverse prognostic marker for low-risk AML.
These results establish that the CRISPR system can be used as a modular and flexible DNA-binding platform for the recruitment of proteins to a target DNA sequence, revealing the potential of CRISPRi as a general tool for the precise regulation of gene expression in eukaryotic cells.
Researchers discuss an integrated methodology based on pooled shRNA screening in mammalian cells for genome-wide identification of genes with relevant phenotypes and systematic mapping of all genetic interactions.
Researchers introduce a computational approach to identify recurrent regions of the genome in noisy data known as cores of recurrent events (CORE), and apply it to comparative genomic hybridization data from a large set of breast cancer samples.
Researchers identiy tens of thousands of putative lincRNAs that are strongly enriched for trait-associated SNPs suggesting a new mechanism by which intergenic trait-associated regions may function.
The emergence and convergence of cancer genomics, targeted therapies, and network oncology have significantly expanded the landscape of protein-protein interaction (PPI) networks.
Researchers explored the effects of FOXO1 mutations in DLBCL patient samples and DLBCL-derived cell lines and suggested FOXO1 mutation as a novel prognostic factor in DLBCL pathogenesis.
Researchers discuss the potentials of high-throughput functional genomics to pinpoint gene-targeted therapies in cancer.