Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

MGC
April 30, 2010
Science

Researchers have sequenced the genome of the western clawed frog (Xenopus tropicalis).

TARGET
February 18, 2010
Blood

TARGET researchers used gene expression profiling to improve their ability to predict the outcome of children with high-risk B-precursor acute lymphoblastic leukemia (ALL).

CGCI
February 01, 2010
Nature Genetics

The study described recurrent somatic mutations in EZH2, a polycomb group oncogene. The mutation, found in the SET domain of this gene encoding a histone methyltransferase, is found only in a subset of lymphoma samples.

CTD²
January 21, 2010
Nature

Researchers discover that two transcription factors C/EBPbeta and STAT3 are responsible for mesenchymal transformation in glioma.

All Programs
January 19, 2010
Cancer Cell

TCGA researchers identified four distinct molecular subtypes of glioblastoma multiforme (GBM), and demonstrated that response to aggressive chemotherapy and radiation differed by subtype.

All Programs
September 20, 2009
Nature Biotechnology

CGEMS researchers announce discovery of new area on chromosome 8 that is associated with risk for prostate cancer.

MGC
September 18, 2009
Genome Research

The MGC Project Team announces the completion of the Mammalian Gene Collection.

TARGET
June 09, 2009
Proceedings of the National Academy of Sciences

Researchers identified a poor prognostic subgroup of pediatric BCR-ABL1-negative ALL patients and reported that the JAK-mutated cases had a gene expression signature similar to BCR-ABL1 pediatric ALL and suggested inhibition of JAK signaling as a target for therapeutic intervention.

All Programs
March 29, 2009
Nature Genetics

CGEMS Researchers have identified new genetic variations in two regions of DNA — located on chromosomes 1 and 14 — that may be associated with the risk of sporadic breast cancer.

TARGET
January 29, 2009
The New England Journal of Medicine

Scientists identified more than 50 recurring copy-number abnormalities in a cohort of patients with B-cell progenitor ALL. Abnormalities were found in genes that encode regulators of B-cell development, PAX5 and IKZF1, a gene that encodes the lymphoid transcription factor IKAROS.

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