Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Researchers have sequenced the genome of the western clawed frog (Xenopus tropicalis).
TARGET researchers used gene expression profiling to improve their ability to predict the outcome of children with high-risk B-precursor acute lymphoblastic leukemia (ALL).
The study described recurrent somatic mutations in EZH2, a polycomb group oncogene. The mutation, found in the SET domain of this gene encoding a histone methyltransferase, is found only in a subset of lymphoma samples.
Researchers discover that two transcription factors C/EBPbeta and STAT3 are responsible for mesenchymal transformation in glioma.
TCGA researchers identified four distinct molecular subtypes of glioblastoma multiforme (GBM), and demonstrated that response to aggressive chemotherapy and radiation differed by subtype.
CGEMS researchers announce discovery of new area on chromosome 8 that is associated with risk for prostate cancer.
The MGC Project Team announces the completion of the Mammalian Gene Collection.
Researchers identified a poor prognostic subgroup of pediatric BCR-ABL1-negative ALL patients and reported that the JAK-mutated cases had a gene expression signature similar to BCR-ABL1 pediatric ALL and suggested inhibition of JAK signaling as a target for therapeutic intervention.
CGEMS Researchers have identified new genetic variations in two regions of DNA — located on chromosomes 1 and 14 — that may be associated with the risk of sporadic breast cancer.
Scientists identified more than 50 recurring copy-number abnormalities in a cohort of patients with B-cell progenitor ALL. Abnormalities were found in genes that encode regulators of B-cell development, PAX5 and IKZF1, a gene that encodes the lymphoid transcription factor IKAROS.