Publications
Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Researchers discuss the potentials of high-throughput functional genomics to pinpoint gene-targeted therapies in cancer.
Analytic Technique for Assessment of RNAi by Similarity (ATARiS) takes advantage of patterns in RNAi data across multiple samples in order to enrich for RNAi reagents whose phenotypic effects relate to suppression of their intended targets.
Researchers show that basal- and luminal-derived prostate tumors have distinct molecular signatures.
TARGET investigators used whole-exome, genome and transcriptome sequencing to determine the spectrum of somatic mutation in high-risk neuroblastoma.
Researchers introduce how CRISPR interference (CRISPRi) can efficiently repress expression of targeted genes in Escherichia coli, with no detectable off-target effects, and can be used to repress multiple target genes simultaneously.
Researchers describe a novel method to discern molecular interactions specific to certain molecular contexts.
The authors use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs and construct double-shRNA libraries from these to systematically measure genetic interactions between hits.
Sequencing the tyrosine kinome and downstream signaling genes in high-risk pediatric ALL cases showed no somatic mutations aside from JAK mutations and 1 FLT3 mutation.
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