Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Through whole exome sequencing, researchers found that pediatric medulloblastoma, the most common malignant brain tumor found in children, contained a fraction of the mutations found in adult cancers and suggested dysregulation of developmental pathways as a mechanism underlying medulloblastomas.
Through unsupervised clustering of gene expression profiling, TARGET researchers discovered eight unique cluster groups among patients with pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL).
Genomic analysis of primary tumors is providing extraordinary insights into the molecular changes in genes and pathways that cause cancer.
Leaders from the NCI Cancer Therapy Evaluation Program (CTEP) and the Children’s Oncology Group provided an overview of the most current childhood cancer statistics.
Researchers have sequenced the genome of the western clawed frog (Xenopus tropicalis).
TARGET researchers used gene expression profiling to improve their ability to predict the outcome of children with high-risk B-precursor acute lymphoblastic leukemia (ALL).
The study described recurrent somatic mutations in EZH2, a polycomb group oncogene. The mutation, found in the SET domain of this gene encoding a histone methyltransferase, is found only in a subset of lymphoma samples.
Researchers discover that two transcription factors C/EBPbeta and STAT3 are responsible for mesenchymal transformation in glioma.
The MGC Project Team announces the completion of the Mammalian Gene Collection.
Researchers identified a poor prognostic subgroup of pediatric BCR-ABL1-negative ALL patients and reported that the JAK-mutated cases had a gene expression signature similar to BCR-ABL1 pediatric ALL and suggested inhibition of JAK signaling as a target for therapeutic intervention.