Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.
* denotes publications from the CTD2 initiative that are results of intra-Network collaborations
Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by oncogenomic screening
The authors screened 124 genes that are amplified in human hepatocellular carcinoma (HCC) using a mouse hepatoblast model and identified 18 tumor-promoting genes, including CCND1 and its neighbor on 11q13.3, FGF19.
In a letter published in Nature Genetics, pediatric researchers found that Native American ancestry is genetically linked with an increased risk of relapse in childhood acute lymphoblastic leukemia (ALL), the most common cancer in children.
Through whole exome sequencing, researchers found that pediatric medulloblastoma, the most common malignant brain tumor found in children, contained a fraction of the mutations found in adult cancers and suggested dysregulation of developmental pathways as a mechanism underlying medulloblastomas.
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome.
Through unsupervised clustering of gene expression profiling, TARGET researchers discovered eight unique cluster groups among patients with pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL).
Genomic analysis of primary tumors is providing extraordinary insights into the molecular changes in genes and pathways that cause cancer.
Leaders from the NCI Cancer Therapy Evaluation Program (CTEP) and the Children’s Oncology Group provided an overview of the most current childhood cancer statistics.
Researchers have sequenced the genome of the western clawed frog (Xenopus tropicalis).
Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia.
TARGET researchers used gene expression profiling to improve their ability to predict the outcome of children with high-risk B-precursor acute lymphoblastic leukemia (ALL).
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.
The study described recurrent somatic mutations in EZH2, a polycomb group oncogene. The mutation, found in the SET domain of this gene encoding a histone methyltransferase, is found only in a subset of lymphoma samples.
Researchers discover that two transcription factors C/EBPbeta and STAT3 are responsible for mesenchymal transformation in glioma.