Publications

Included here is a list of publications from OCG programs. All published data are available to the research community through the program-specific data matrices.

* denotes publications from the CTD2 initiative that are results of intra-Network collaborations

 

CTD²
May 03, 2018
Cell

CTD2 scientists at UTSW employed a chemistry-first approach to map the associations between chemicals and genetic lesions in lung cancer. These chemical vulnerabilities may reveal novel druggable targets for lung cancer.

CTD²
TARGET
May 01, 2018
Cancer Discovery

Scientists proposed a framework to investigate the genomic alterations in neuroblastoma subtypes and identified TEAD4, a transcription factor, as a novel target for therapy.

CTD²
April 25, 2018
Cell Systems

Researchers at the UCSD CTD2 Center created a parsimonious composite network (PCNet), which has high efficiency and performance over any single network.

CTD²
April 24, 2018
Bioinformatics

Broad Institute CTD2 scientists developed a bioinformatic approach, RWEN, that predicts the responses of human cancer cell lines to a panel of compounds using the gene-expression profiles.

CTD²
April 17, 2018
Cell Reports

CTD2 researchers at UCSF-1 present a quantitative map linking the influence of chemotherapeutic agents to tumor genetics. This chemical-genetic interaction map can aid in identifying new factors that dictate responses to chemotherapy and prioritize drug combinations.

CTD²
April 16, 2018
Nature Communications

Scientists developed metaVIPER to assess protein activity in orphan tissues and single cells by integrative analysis of multiple, non-tissue-matched regulatory models. This approach could help to identify critical dependencies within molecularly heterogeneous sub-populations of cancer tissues.

CTD²
April 14, 2018
Bioinformatics

Researchers developed MethylMix 2.0, an algorithm implemented in R that facilitates automated downloading and preprocessing of DNA methylation and gene expression datasets from pan-cancer studies. The tool can be used to identify disease specific hyper and hypomethylated genes and cancer subtyping.

CTD²
April 09, 2018
Developmental Cell

Researchers at Johns Hopkins School of Medicine CTD2 Center use multidisciplinary studies to define a set of mechanical properties and cell behaviors to study how cells collaborate to elongate epithelial tubes. These studies will enable the understanding of cell migration through tissues.

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