β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis

December 21, 2012

This work combined loss-of-function screening data mined from Project Achilles, a project partially supported by CTD², and gene expression/copy number analyses from the Cancer Cell Line Encyclopedia, with new β-catenin activity data across 85 cell lines. The integration of these data types allowed identification of 50 genes upon which β-catenin dependent cells preferentially rely for survival, including a number of genes related to the transcriptional regulator YAP1. Indeed, YAP1 was also required for tumor growth in a β-catenin dependent orthotopic colon tumor model. By further characterizing YAP1/β-catenin-mediated transformation, the group was able to find several factors linked to YAP1 that appear to be targetable with small molecules and might be suitable for use in future therapies.

 

Program:
CTD²
Last updated: October 30, 2018