A large number of gene mutations give proteins new capabilities to bind cellular proteins and create new signaling pathways that drive tumor growth. To discover and validate mutation-created protein-protein interactions (PPI) as therapeutic targets for cancer, the CTD² Center at Emory University has created PPI expression vector libraries. A list of available cancer-associated genes can be accessed here: Emory_CTD^2_PPI_Reagents.xlsx [1]

Contact: Haian Fu [2] 

Li Z, et al. The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Nature Communications. 2017 Feb 16;8:14356. (PMID: 28205554 [3])