Office of Cancer Genomics
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Home > Protein-Protein Interaction (PPI) Reagents

Wednesday, February 15, 2017

A large number of gene mutations give proteins new capabilities to bind cellular proteins and create new signaling pathways that drive tumor growth. To discover and validate mutation-created protein-protein interactions (PPI) as therapeutic targets for cancer, the CTD2 Center at Emory University has created PPI expression vector libraries. A list of available cancer-associated genes can be accessed here: FileEmory_CTD^2_PPI_Reagents.xlsx [1]

Contact: Haian Fu [2] 

Li Z, et al. The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies. Nature Communications. 2017 Feb 16;8:14356. (PMID: 28205554 [3])

Resource Type: 
For Investigators [4]
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Source URL:https://ocg.cancer.gov/resources/protein-protein-interaction-ppi-reagents

Links
[1] https://ocg.cancer.gov/sites/default/files/Emory_CTD%5E2_PPI_Reagents.xlsx [2] mailto:mailto:hfu@emory.edu?subject=Protein-Protein%20Interactions%20(PPI)%20Reagents [3] https://pubmed.ncbi.nlm.nih.gov/28205554/ [4] https://ocg.cancer.gov/resource-types/investigators