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The Panorama of Cancer Genetics [1]

Genomics of Gene Regulation

Genomics of Gene Regulation (Credit: Darryl Leja, NHGRI)

Bader JS.

Cancer Res.

May 15, 2021

Cancer, a disease of the genome, is caused by a combination of germline predisposing variants and acquired somatic mutations. A unified view of heritable and acquired genetic factors will improve our understanding of cancer occurrence and progression. Fanfani and colleagues provide new insight into heritable cancer risk through a computational method that identifies genes and loci that contribute strongly to cancer heritability; many of these loci also harbor somatic drivers. Beyond improving cancer clinical outcomes, these methods will also be valuable across complex disorders by identifying regions responsible for missing heritability.

https://pubmed.ncbi.nlm.nih.gov/33999839/ [2]
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Source URL:https://ocg.cancer.gov/news-publications/publications/panorama-cancer-genetics

Links
[1] https://ocg.cancer.gov/news-publications/publications/panorama-cancer-genetics [2] https://pubmed.ncbi.nlm.nih.gov/33999839/