OCG facilitates cancer genomics research through a series of highly-focused programs. These programs generate and disseminate genomic data for use by the cancer research community. OCG programs also promote advances in technology-based infrastructure and create valuable experimental reagents and tools. OCG programs encourage collaboration by interconnecting with other genomics and cancer projects in order to accelerate translation of findings into the clinic.

Below are OCG’s current, completed, and initiated programs:

Current Programs

Cancer Genome Characterization Initiative Banner. Links to Program Page

CGCI supports research to comprehensively catalog the genomic alterations in adult and pediatric cancers. The research community can use CGCI data to gain insight into the underlying mechanisms of these cancers and identify potential therapeutic targets.

View CGCI Program Page >

CTD2 bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics. It specializes in computational and functional genomics approaches critical for translating next-generation sequencing data, as well as high-throughput and high content small molecule and genetic screens.

View CTD² Program Page >
Banner for Human Cancer Model Initiative

The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel human tumor-derived culture models, which are annotated with genomic and clinical data. In an effort to advance cancer research and more fully understand how in vitro findings are related to clinical biology, HCMI-developed models and related data will be available as a community resource for cancer research.

View HCMI Program Page >
Therapeutically Applicable Research To Generate Effective Treatments Program Banner

TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. Investigators form a collaborative network to facilitate discovery of molecular targets and translate those findings into the clinic. TARGET is managed by NCI’s Office of Cancer Genomics and Cancer Therapy Evaluation Program.

View TARGET Program Page >

Completed Programs

Cancer Genome Anatomy Project

CGAP: Cancer Genome Anatomy Project

The National Cancer Institute (NCI) Cancer Genome Anatomy Project (CGAP) is an online resource designed to provide the research community access to biological tissue characterization data. Request a free copy of the CGAP Website Virtual Tour CD from

View CGAP Program Website >
Initiative for Chemical Genetics

ICG: Initiative for Chemical Genetics

The Initiative for Chemical Genetics provides a systematic approach to studying biology through small molecule probes and screens, so that new therapies for diseases like cancer can be developed.

View ICG Program Website >
NIH Mammalian Gene Collection

MGC: NIH Mammalian Gene Collection

The goal of the Mammalian Gene Collection (MGC), a trans-NIH initiative, was to provide full-length open reading frame (FL-ORF) clones for human, mouse, cow, and rat genes.

View MGC Program Website >

Initiated Programs

The Cancer Genome Atlas

TCGA: The Cancer Genome Atlas

The National Institutes of Health (NIH) established The Cancer Genome Atlas (TCGA) to generate comprehensive, multi-dimensional maps of the key genomic changes in major types and subtypes of cancer.

View TCGA Program Website >
Last updated: May 23, 2018