OCG programs support research on structural, functional, and translational genomics, as well as the development of next-generation cancer models. These programs promote advances in technology and provide accessibility to data, tools, and reagents for the research community worldwide. OCG programs interconnect with other genomics and translational projects in order to accelerate discoveries into the clinic and improve patient outcomes.
Below are OCG’s current, completed, and initiated programs:
The Cancer Genome Characterization Initiative (CGCI) uses molecular characterization to uncover distinct features of rare cancers. Current projects perform comprehensive molecular cataloging of HIV+ and other rare adult and pediatric cancers. The research community can use CGCI data to gain insights into the underlying mechanisms of these cancers and identify potential therapeutic targets.
The Cancer Target Discovery and Development (CTD2) Network, a functional genomics initiative, bridges the gap between cancer genomics and biology. The Network aims to understand how tumor heterogeneity leads to drug resistance in order to develop optimal combinations of chemotherapy or small molecules in combination with immunotherapy.
The Human Cancer Models Initiative (HCMI) is a collaborative international consortium that is generating novel, next-generation, tumor-derived culture models annotated with genomic and clinical data. HCMI-developed models and related data are available as a community resource. The NCI is contributing to the initiative by supporting four Cancer Model Development Centers (CMDCs).
The Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. The goal of the program is to use data to guide the development of effective, less toxic therapies. TARGET is organized into a collaborative network of disease-specific project teams.
CGAP: Cancer Genome Anatomy Project
The National Cancer Institute’s (NCI) Cancer Genome Anatomy Project (CGAP) provides the only online Mitelman database for chromosomal aberrations in cancer. This resource includes access to biological tissue characterization data as well as tools to analyze these data. Request a free copy of the CGAP Website Virtual Tour CD from firstname.lastname@example.org.
ICG: Initiative for Chemical Genetics
The Initiative for Chemical Genetics (ICG) provides a systematic approach to studying biology through small molecule probes and screens so that new therapies for diseases like cancer can be developed.
MGC: NIH Mammalian Gene Collection
The Mammalian Gene Collection (MGC) provides an open access bank of full-length open reading frame (FL-ORF) clones for human, mouse, cow, rat, xenopus, and zebrafish genes.
TCGA: The Cancer Genome Atlas
The National Institutes of Health (NIH) established The Cancer Genome Atlas (TCGA) to generate comprehensive, multi-dimensional maps of the key genomic changes in major types and subtypes of cancer.