CGCI supports research to comprehensively catalog the genomic alterations in adult and pediatric cancers. The research community can use CGCI data to gain insight into the underlying mechanisms of these cancers and identify potential therapeutic targets.
OCG facilitates cancer genomics research through a series of highly-focused programs. These programs generate and disseminate genomic data for use by the cancer research community. OCG programs also promote advances in technology-based infrastructure and create valuable experimental reagents and tools. OCG programs encourage collaboration by interconnecting with other genomics and cancer projects in order to accelerate translation of findings into the clinic.
Below are OCG’s current, completed, and initiated programs:
CTD2 bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics. It specializes in computational and functional genomics approaches critical for translating next-generation sequencing data, as well as high-throughput and high content small molecule and genetic screens.
The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel human tumor-derived culture models, which are annotated with genomic and clinical data. In an effort to advance cancer research and more fully understand how in vitro findings are related to clinical biology, HCMI-developed models and related data will be available as a community resource for cancer research. The National Cancer Institute (NCI) is contributing to this international consortium by providing funding and support to two Cancer Model Development Centers (CMDCs). The CMDCs will develop next-generation cancer models from patient tissue. Visit the Cancer Model Development Centers page for an introduction to the NCI's CMDCs.
TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. Investigators form a collaborative network to facilitate discovery of molecular targets and translate those findings into the clinic. TARGET is managed by NCI’s Office of Cancer Genomics and Cancer Therapy Evaluation Program.
CGAP: Cancer Genome Anatomy Project
The National Cancer Institute (NCI) Cancer Genome Anatomy Project (CGAP) is an online resource designed to provide the research community access to biological tissue characterization data. Request a free copy of the CGAP Website Virtual Tour CD from firstname.lastname@example.org.
ICG: Initiative for Chemical Genetics
The Initiative for Chemical Genetics provides a systematic approach to studying biology through small molecule probes and screens, so that new therapies for diseases like cancer can be developed.
MGC: NIH Mammalian Gene Collection
The goal of the Mammalian Gene Collection (MGC), a trans-NIH initiative, was to provide full-length open reading frame (FL-ORF) clones for human, mouse, cow, and rat genes.
TCGA: The Cancer Genome Atlas
The National Institutes of Health (NIH) established The Cancer Genome Atlas (TCGA) to generate comprehensive, multi-dimensional maps of the key genomic changes in major types and subtypes of cancer.