HCMI: Human Cancer Models Initiative

The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel human tumor-derived culture models, which are annotated with genomic and clinical data. In an effort to advance cancer research and more fully understand how in vitro findings are related to clinical biology, HCMI-developed models and related data will be available as a community resource for cancer research. The National Cancer Institute (NCI) is contributing to this international consortium by providing funding and support to two Cancer Model Development Centers (CMDCs). The CMDCs will develop next-generation cancer models from patient tissue. Visit the Cancer Model Development Centers page for an introduction to the NCI's CMDCs.

HCMI will create cancer models from a wide variety of tumor types, and make them available for researchers around the globe. These reagents can be used to better understand cancer biology and help develop better therapies.

News & Publications

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genomic data commons graphic
June 06, 2016

The NCI’s Center for Cancer Genomics launches the Genomic Data Commons (GDC), a unified data sharing platform for the cancer research community. The mission of the GDC is to enable data sharing across the entire cancer research community, to ultimately...

picture of scientist
May 10, 2016

As part of the Vice President’s National Cancer Moonshot Initiative, the National Cancer Institute has launched an online engagement platform to enable the research community and the public to submit cancer research ideas to a...

ORFeome gene graph
March 04, 2016

The ORFeome Collaboration (OC) is a team of academic and commercial entities which have generated the largest collection of clones containing verified open-reading frames (ORFs) of known human genes. The clones are made available to researchers worldwide through multiple distributors. This...

April 15, 2015

The National Cancer Institute (NCI) has launched the Center for Cancer Genomics (CCG) website within www.cancer.gov to provide an overview of CCG programs, collaborative efforts, events, and more!

CCG was established to unify NCI’s...

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Last updated: February 16, 2017