The Human Cancer Models Initiative (HCMI) is an international consortium that is generating novel human tumor-derived culture models, which are annotated with genomic and clinical data. In an effort to advance cancer research and more fully understand how in vitro findings are related to clinical biology, HCMI-developed models and related data will be available as a community resource for cancer and other research. The National Cancer Institute (NCI) is contributing to this international consortium by providing funding and support to two Cancer Model Development Centers (CMDCs). The CMDCs will develop next-generation cancer models from patient tissue. Visit the Cancer Model Development Centers page for an introduction to the NCI's CMDCs.