5 Publications Available
August 15, 2013

By utilizing whole-genome sequencing, DNA copy number analysis and RNA-seq, researchers discovered recurrent somatic point mutations and genes that were targeted by focal somatic deletions in diffuse large B-cell lymphoma (DLBCL).

May 02, 2013

Researchers explored the effects of FOXO1 mutations in DLBCL patient samples and DLBCL-derived cell lines and suggested FOXO1 mutation as a novel prognostic factor in DLBCL pathogenesis.

May 24, 2012

The study identified a recurrent somatic novel gene fusion between TBL1XR1 and TP63 by analyzing transcriptome data from 96 DLBCL cases.

July 27, 2011

Morin et al. uncovered a novel role for chromatin modification in driving the progression of two non-Hodgkin lymphomas (NHLs), follicular lymphoma and diffuse large B-cell lymphoma.

February 01, 2010
Nature Genetics

The study described recurrent somatic mutations in EZH2, a polycomb group oncogene. The mutation, found in the SET domain of this gene encoding a histone methyltransferase, is found only in a subset of lymphoma samples.