CTD²: Cancer Target Discovery and Development

CTD2 bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics. It specializes in computational and functional genomics approaches critical for translating next-generation sequencing data, as well as high-throughput and high content small molecule and genetic screens.

Cancer Target Discovery and Development

News & Publications

Image by the University of Michigan School of Natural Resources and Environment; used under a Creative Commons license.  
August 01, 2016

The Cancer Target Discovery and Development (CTD^2) Network was established to accelerate the transformation of "Big Data" into novel pharmacological targets, lead compounds, and biomarkers for rapid translation into improved patient outcomes. It rapidly became clear in this collaborative...

Cancer Target Discovery and Development Logo
July 18, 2016

NCI's Office of Cancer Genomics has released a new Funding Opportunity Announcement (FOA). This FOA will continue to support the program "Cancer Target Discovery and Development” (CTD^2, pronounced cee-tee-dee-squared).  CTD^2 is focused on efforts that advance cancer research by bridging the...

Human Cancer Models Initiative Banner
July 11, 2016

The NCI Office of Cancer Genomics, along with Cancer Research UK, foundation...

July 06, 2016

Cancer genome characterization efforts now provide an initial view of the somatic alterations in primary tumors. However, most point mutations occur at low frequency, and the function of these alleles remains undefined. We have developed a scalable systematic approach to interrogate the function...

Overview of VIPER method
June 20, 2016

Identifying the multiple dysregulated oncoproteins that contribute to tumorigenesis in a given patient is crucial for developing personalized treatment plans. However, accurate inference of aberrant protein activity in biological samples is still challenging as genetic alterations are only...

Last updated: October 21, 2015