CTD²: Cancer Target Discovery and Development

CTD2 bridges the gap between the enormous volumes of data generated by genomic characterization studies and the ability to use these data for the development of human cancer therapeutics. It specializes in computational and functional genomics approaches critical for translating next-generation sequencing data.

Cancer Target Discovery and Development

News & Publications

Model of altretamine, an anti-cancer drug that the authors found acts through a mechanism similar to sulfasalazine. Image from Wikimedia Commons.
July 25, 2015

Genome-wide identification of the mechanism of action (MoA) of small-molecule compounds characterizing their targets, effectors, and activity modulators represents a highly...

Image of the Dashboard landing page. The CTD2 Dashboard is a portal to browse and search positive results from the Network.
April 16, 2015

The CTD2 Dashboard hosts analyzed data and other evidence generated by the CTD2 Network. It is a web interface for the research community to browse and search CTD2 Network data related to genes, proteins, and compounds from individual CTD2 Centers, or...

Image of Breast Cancer tissue
April 16, 2015

Targeting HER2 with antibodies or small molecule inhibitors in HER2-positive breast cancer leads to improved survival, but resistance is a common clinical problem. To uncover novel mechanisms of resistance to anti-HER2 therapy in breast cancer, we performed a kinase open reading frame screen to...

Last updated: June 15, 2015