CTD² Centers

CTD² is comprised of 13 OCG-supported research teams, called Centers. Each Center is based in a US academic institution and led by principal investigators. Fred Hutchinson Cancer Research Center and University of California, San Francisco host two Centers each.

Map of the CTD² Centers

The Centers work independently and collaboratively as a unified “Network” to functionally validate discoveries from large-scale genomic initiatives and advance them toward precision medicine. They share data and resources, such as analytical tools and reagents, across the Network and with the research community.

Each Center contributes unique expertise in one or more of the following areas:

  • In-depth mining of large-scale genomic data
  • Systems biology analyses
  • High-throughput screening of small molecules or genetic perturbagens
  • In vitro and in vivo biological characterization approaches
  • Technology development and improvement

Through these and other experimental approaches, the Network identifies genes and proteins that drive cancer initiation, maintenance and/or progression. Some of these may serve as biomarkers or targets, which may ultimately be useful for diagnostic, prognostic, or therapeutic purposes.

The following descriptions inform what each Center is contributing to the Network and the greater research community.