The Cancer Target Discovery and Development (CTD2) Network aims to understand the mechanisms of tumor progression, heterogeneity, and drug resistance and applies the knowledge for the development of efficient strategies to identify optimal combinations of small-molecules or immunotherapy with small molecules. The CTD2 is a “community resource project” and Network members release their data to the Data Portal and Dashboard so that other investigators can utilize it and thereby maximize the impact of the findings.
Data generated by CTD2 Network teams can be accessed through the Data Portal and the Dashboard. The CTD2 Data Portal provides access to raw/analyzed primary data generated from different types of experimental and computational approaches. Examples of data types on the Data Portal include chemical genetic screens (small-molecules, natural products); genome-wide gain-of-function (cDNA expression libraries, CRISPRa); genome-wide loss-of-function (siRNA, shRNA, CRISPR/Cas9, CRISPRi); and protein-protein interactions, etc. The Data Portal contains a wealth of information: brief descriptions of research projects, experimental approaches, links to download raw/primary data, and links to associated validated studies in the Dashboard. Not all projects on the Data Portal have links to Dashboard submissions as the follow-up studies of the primary screening may be in progress or not yet pursued.
The CTD2 Dashboard is an interactive web database that hosts positive results and allows users to connect targets, biomarkers, and modulators with evidence to support the validation. It allows easy navigation to computational and non-computational biologists. To learn more about the functionalities, watch the tutorial videos: Understanding the Dashboard; Searching and Browsing; Identifying Molecular Interactions.
