August 01, 2018
Cold Spring Harbor Perspectives in Medicine
July 30, 2018

Genome-scale open reading frame screen identifies RNA binding proteins, QK1 and RBFOX1, regulate the alternate splicing of actin binding protein, FLNB. The skipping of FLNB exon 30 is associated with the transition to mesenchymal- and stem-like cell states in breast cancer pathogenesis.

July 19, 2018
Molecular Cell

Scientists at DFCI demonstrated that binding of transcription factor, ERG, to chromatin remodeling complex, BAF, is essential to facilitate basal-to-luminal transition, a hallmark of prostate oncogenesis.

July 17, 2018

Researchers at UCSF developed an analytical framework for constructing a human genetic interaction map, a powerful tool to identify genetic interactions between genes and suggest new combination therapies for cancer.

July 16, 2018
Nature Communications

In vivo functional screening identifies transcriptional repressor, GATAD2B, as a potent driver of tumor growth and metastasis in KRAS-mutant lung cancer through interaction with c-Myc.

July 16, 2018
Nature Communications

In vivo gain-of-function genetic screen identifies TMEMB, a transmembrane protein as a novel driver of invasion and metastasis in lung cancer.