556 Publications Available
October 22, 2019
Journal of Molecular Cell Biology

Emory University CTD2 scientists showed that NSD3S plays a critical role in the regulation of MYC function through inhibition of FBXW7-mediated degradation of MYC. This interaction drives cancer cell survival and could be a potential therapeutic target in MYC-driven tumors.

October 08, 2019
Blood Advances

Epigenomic analysis of methylation data using Onco-GPS computational approach identify subtypes of myelodysplastic syndromes. The subtypes had distinct patterns of genetic lesions, regulatory region methylation, and prognostic response.

October 04, 2019
Protein-Protein Interaction Networks: Book Chapter
September 25, 2019
Nature Communications

Metabolic profiling of serum samples indicated an increase in kynurenine in melanoma and renal cell carcinoma patients treated with immune-checkpoint inhibitor, nivolumab. An increase in kynurenine, a product of tryptophan catabolism, correlates with worse overall survival.

September 19, 2019
Cell Chemical Biology

Scientists at the Broad Institute CTD2 Center identified 6-phosphogluconate dehydrogenase, a cytosolic enzyme as a link between carbohydrate metabolism and protein secretion.

September 13, 2019
Expert Review of Proteomics

A review article on understanding ovarian cancer at the protein-level using large-scale proteomic technologies and proteomic studies.

September 05, 2019
Cell Stem Cell

CTD2 scientists at UCSF showed that neuroepithelial stem cells derived from normal induced pluripotent stem cells could be a powerful experimental resource to evaluate genetic mutations in medulloblastoma.

September 01, 2019

Scientists at Johns Hopkins University showed that E-cadherin is an essential factor in the seeding phases of metastasis in invasive ductal carcinomas. This is mediated by limiting reactive oxygen-mediated apoptosis.