* denotes a publication that resulted from CTD2 intra-Network collaborations
Researchers document coexpression of EGFR and EGFRvIII in primary human glioblastoma that drives transformation and tumorigenesis in a cell-intrinsic manner and clarify specific oncogenic signaling relationships in glioblastoma.
Author comment on Dual blockade of the PI3K/AKT/mTOR(AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergystically inhibits rhabdomyosarcoma...
A review on the role of MYCN and other newly identifed drivers in neuroblastoma.
A collaborative effort to compare the molecular changes across the original 12 tumor types profiled by The Cancer Genome Atlas.
Using a newly developed platform to identify the signaling pathway/molecular target of natural products, we identified a family of alkaloid natural products, discoipyrroles A-D (1-4), from Bacillus hunanensis that inhibit the DDR2 signaling pathway.
3q26 is frequently amplified in several cancer types with a common amplified region containing 20 genes. To identify cancer driver genes in this region, we interrogated the function of each of these genes.
The Cancer Therapeutics Response Portal (www.broadinstitute.org/ctrp) was created to identify cancer genotype-compound sensitivity relationships.
Researchers introduce the PiHelper, which integrates human drug-target and antibody-target associations from publicly available resources to help meet the needs of researchers in systems pharmacology, perturbation biology and proteomics.
Using nanofluidic proteomic immunoassay researchers demonstrate that under basal and ligand-induced conditions that the pattern of phosphorylation events is markedly different between AKT1 and AKT2.