Publications

613 Publications Available
March 01, 2013
Nature Cell Biology

Researchers show that basal- and luminal-derived prostate tumors have distinct molecular signatures.

February 28, 2013
Cell

Researchers introduce how CRISPR interference (CRISPRi) can efficiently repress expression of targeted genes in Escherichia coli, with no detectable off-target effects, and can be used to repress multiple target genes simultaneously.

February 19, 2013
BMC Genomics

Researchers describe a novel method to discern molecular interactions specific to certain molecular contexts.

February 14, 2013
Cell

The authors use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs and construct double-shRNA libraries from these to systematically measure genetic interactions between hits.

December 21, 2012
Cell

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers; emerging evidence indicates that oncogenic β-catenin regulates several biological processes essential for cancer initiation and progression.

November 08, 2012
Future Oncology

Researchers evaluate blocking the MET pathway to prevent post-bevacizumab treatment tumor recurrence, providing a strong rationale for using a combination of MET and VEGF receptor inhibitors to treat glioblastoma patients.

October 01, 2012
Genome Research

Researchers have developed an integrated systems-biology approach to identifying novel cancer genes contributing to endometrial tumorigenesis. Their results revealed 12 potential driver cancer genes including 10 tumor-suppressor candidates and two oncogene candidates.

September 15, 2012
Cancer Research

Researchers created a mouse model of prostate cancer with inducuble PTEN disruption plus BRAF(V600E) expression.

August 17, 2012
Cell

A group of researchers, including a member of the CTD² network, has identified 56 candidate genes upon which cancer cells are uniquely dependent for survival.

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