613 Publications Available
March 01, 2013
Nature Cell Biology

Researchers show that basal- and luminal-derived prostate tumors have distinct molecular signatures.

February 28, 2013

Researchers introduce how CRISPR interference (CRISPRi) can efficiently repress expression of targeted genes in Escherichia coli, with no detectable off-target effects, and can be used to repress multiple target genes simultaneously.

February 19, 2013
BMC Genomics

Researchers describe a novel method to discern molecular interactions specific to certain molecular contexts.

February 14, 2013

The authors use ultracomplex pooled shRNA libraries (25 shRNAs/gene) to identify high-confidence hit genes for a given phenotype and effective shRNAs and construct double-shRNA libraries from these to systematically measure genetic interactions between hits.

December 21, 2012

Wnt/β-catenin signaling plays a key role in the pathogenesis of colon and other cancers; emerging evidence indicates that oncogenic β-catenin regulates several biological processes essential for cancer initiation and progression.

November 08, 2012
Future Oncology

Researchers evaluate blocking the MET pathway to prevent post-bevacizumab treatment tumor recurrence, providing a strong rationale for using a combination of MET and VEGF receptor inhibitors to treat glioblastoma patients.

October 01, 2012
Genome Research

Researchers have developed an integrated systems-biology approach to identifying novel cancer genes contributing to endometrial tumorigenesis. Their results revealed 12 potential driver cancer genes including 10 tumor-suppressor candidates and two oncogene candidates.

September 15, 2012
Cancer Research

Researchers created a mouse model of prostate cancer with inducuble PTEN disruption plus BRAF(V600E) expression.

August 17, 2012

A group of researchers, including a member of the CTD² network, has identified 56 candidate genes upon which cancer cells are uniquely dependent for survival.