The CTD² Network sponsored Dialogue on Reverse Engineering and Assessment Methods (DREAM) Challenges powered by Sage Bionetworks; invites the community to develop predictive bioinformatics models. Visit the CTD² Pancancer Chemosensitivity DREAM Challenge registration site for details.
Publications
556 Publications Available
September 01, 2019
Nature
Scientists at Johns Hopkins University showed that E-cadherin is an essential factor in the seeding phases of metastasis in invasive ductal carcinomas. This is mediated by limiting reactive oxygen-mediated apoptosis.
August 27, 2019
iScience
This study shows that transient overexpression of cyclin E in mammary epithelial cells generated chromosomal copy number alterations (CNAs) signatures. These CNAs can be translated to changes in gene expression patterns that drive tumor growth.
August 27, 2019
Cell Reports
Small-molecule and genome-scale CRISPR knock-out screens revealed that receptor tyrosine kinases and small heterodimer partner2 are vulnerabilities in rhabdoid tumor cell lines.
August 23, 2019
Science
Scientists at UCSF developed a new analytical framework, GI manifold, for mapping and understanding genetic interactions. This approach describes the transcriptional states that a cell can occupy upon perturbation and could help in identifying synthetic lethal genetic interactions in cancer.
August 09, 2019
Science
Saturated mutagenesis screen showed that p53 missense mutations in the DNA-binding domain exert a dominant-negative effect. This is a primary unit of selection for TP53 missense mutations.
August 07, 2019
Journal of Theoretical Biology
UCSD researchers developed a framework to simulate population dynamics of heterogeneous tumor cells with a reversible mechanism of resistance. The study provides insights to optimal cancer treatment methods and may guide the development of therapeutic strategies to evade drug resistance.
August 01, 2019
Cancer Discovery
Study reports that the third-generation pan-FGFR inhibitor, TAS-120, overcomes resistance to several FGFR2 mutations; leads to personalized targeted therapy in FGFR-activated intrahepatic cholangiocarcinoma.
August 01, 2019
International Journal of Oncology
Researchers at the Emory CTD2 Center showed transcription factor, SOX4, knockdown induced WNT5a expression and increased WNT5a expression are associated with decreased invasive ability in bladder cancer cells.
July 29, 2019
PLoS Compuational Biology
Bioinformatic approach, MethylMix analysis, refines nominations for epigenetic driver genes by leveraging quantitative high-throughput proteomic data to select only genes where DNA methylation is predictive of protein abundance.
July 22, 2019
Journal of Clinical Investigation
UCSF scientists demonstrated that neomorphic fusion oncoprotein, CIC-DUX4, controls capicua-regulated transcriptional pathways to promote hallmark features of malignancy like tumor cell survival, growth, and metastasis.
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