509 Publications Available
August 13, 2018
Nature Cell Biology

CTD2 researchers at UCSF showed that SHP2, a non-receptor protein tyrosine phosphatase, could be a potential molecular target in cancers driven by oncogenic mutants of RAS/MAPK pathway.

August 13, 2018
Journal of Clinical Pathology

Review on the role of CDK12 as a clinical biomarker and as a potential therapeutic target for cancer therapy.

August 08, 2018
Trends in Cancer

A review article on using the patient-derived cancer models for the identification of targets to overcome roadblocks of precision oncology.

August 01, 2018
Cold Spring Harbor Perspectives in Medicine
July 30, 2018

Genome-scale open reading frame screen identifies RNA binding proteins, QK1 and RBFOX1, regulate the alternate splicing of actin binding protein, FLNB. The skipping of FLNB exon 30 is associated with the transition to mesenchymal- and stem-like cell states in breast cancer pathogenesis.

July 19, 2018
Molecular Cell

Scientists at DFCI demonstrated that binding of transcription factor, ERG, to chromatin remodeling complex, BAF, is essential to facilitate basal-to-luminal transition, a hallmark of prostate oncogenesis.

July 17, 2018

Researchers at UCSF developed an analytical framework for constructing a human genetic interaction map, a powerful tool to identify genetic interactions between genes and suggest new combination therapies for cancer.