TARGET: Therapeutically Applicable Research to Generate Effective Treatments

TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. Investigators form a collaborative network to facilitate discovery of molecular targets and translate those findings into the clinic. TARGET is managed by NCI’s Office of Cancer Genomics and Cancer Therapy Evaluation Program.

Therapeutically Applicable Research to Generate Effective Treatments

News & Publications

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May 13, 2016

A new funding opportunity aims to generate novel human tumor-derived culture models that will be made accessible to scientists around the world.

Most cancer cell lines that are commonly used in research labs today were established decades ago and have been propagated in culture for many...

picture of scientist
May 10, 2016

As part of the Vice President’s National Cancer Moonshot Initiative, the National Cancer Institute has launched an online engagement platform to enable the research community and the public to submit cancer research ideas to a...

Pathology of rhabdoid tumor
March 14, 2016

Malignant rhabdoid tumors (MRTs) are rare lethal tumors of childhood that most commonly occur in the kidney and brain. MRTs are driven by SMARCB1 loss, but the molecular consequences...

ORFeome gene graph
March 04, 2016

The ORFeome Collaboration (OC) is a team of academic and commercial entities which have generated the largest collection of clones containing verified open-reading frames (ORFs) of known human genes. The clones are made available to researchers worldwide through multiple distributors. This...

Young girl in grass
March 03, 2016

The genomic and clinical information used to develop and implement therapeutic approaches for AML originated primarily from adult patients and has been generalized to patients with pediatric AML. However, age-specific molecular alterations are becoming more evident and may signify the need to...

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Projects

Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a cancer of white blood cells, the cells in the body that normally fight infection.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a cancer that originates in the bone marrow from immature white blood cells known as myeloblasts. About 25% of all children with leukemia have AML. 

Kidney Tumors

Pediatric kidney tumors fall into four primary categories: Wilms tumors (~85% of all cases), clear cell sarcomas of the kidney (~5%), congenital mesoblastic nephromas (~4%), and rhabdoid tumors of the kidney (~3%). The TARGET initiative is investigating three of these tumor types.

Neuroblastoma

Neuroblastoma (NBL) is a cancer that arises in immature nerve cells of the sympathetic nervous system, primarily affecting infants and children.

Osteosarcoma

Osteosarcoma (OS) is the most common type of bone cancer in children and adolescents.

Last updated: April 29, 2016