TARGET: Therapeutically Applicable Research to Generate Effective Treatments

TARGET applies a comprehensive genomic approach to determine molecular changes that drive childhood cancers. Investigators form a collaborative network to facilitate discovery of molecular targets and translate those findings into the clinic. TARGET is managed by NCI’s Office of Cancer Genomics and Cancer Therapy Evaluation Program.

Therapeutically Applicable Research to Generate Effective Treatments

News & Publications

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Scanning electron microscopy of Wilms tumor
October 04, 2016

Purpose: To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumors (DAWTs).

Experimental Design: All DAWTs registered on National Wilms Tumor Study-5 (n = 118) with available samples were...

Human Cancer Models Initiative Banner
July 11, 2016

The NCI Office of Cancer Genomics, along with Cancer Research UK, foundation...

genomic data commons graphic
June 06, 2016

The NCI’s Center for Cancer Genomics launches the Genomic Data Commons (GDC), a unified data sharing platform for the cancer research community. The mission of the GDC is to enable data sharing across the entire cancer research community, to ultimately...

picture of scientist
May 10, 2016

As part of the Vice President’s National Cancer Moonshot Initiative, the National Cancer Institute has launched an online engagement platform to enable the research community and the public to submit cancer research ideas to a...

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Projects

Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a cancer of white blood cells, the cells in the body that normally fight infection.

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a cancer that originates in the bone marrow from immature white blood cells known as myeloblasts. About 25% of all children with leukemia have AML. 

Kidney Tumors

Pediatric kidney tumors fall into four primary categories: Wilms tumors (~85% of all cases), clear cell sarcomas of the kidney (~5%), congenital mesoblastic nephromas (~4%), and rhabdoid tumors of the kidney (~3%). The TARGET initiative is investigating three of these tumor types.

Neuroblastoma

Neuroblastoma (NBL) is a cancer that arises in immature nerve cells of the sympathetic nervous system, primarily affecting infants and children.

Osteosarcoma

Osteosarcoma (OS) is the most common type of bone cancer in children and adolescents.

Last updated: December 08, 2016