Acute Myeloid Leukemia

The TARGET Acute Myeloid Leukemia projects elucidate comprehensive molecular characterization to determine the genetic changes that drive the initiation and progression of high-risk or hard-to-treat childhood cancers. Acute myeloid leukemia (AML) is a cancer that originates in the bone marrow from immature white blood cells known as myeloblasts. About 25% of all children with leukemia have AML. Although survival rates have increased since the 1970s, approximately half of all childhood AML cases relapse despite intensive treatment. Additional therapies following relapse are often unsuccessful and can be especially difficult and damaging for children. These patients would clearly benefit from targeted therapeutic approaches.

Through comprehensive genome-wide characterization, TARGET researchers are identifying the genetic and epigenetic alterations of relapsed disease. The ultimate goal is to translate their discoveries into novel treatments that will improve outcomes for children with AML. To learn more about pediatric AML and current treatment strategies, visit the NCI pediatric AML website.

The AML project is currently working on publications to include an integrated manuscript of the disease landscape. Please refer to the TARGET Publication Guidelines page to see which AML datasets are available without restrictions on their use in publications or presentations.

Last updated: August 18, 2017