October 04, 2016
Clinical Cancer Research

TARGET investigators report on the key role that loss of TP53 plays in the development of anaplasia in Wilms tumors and may reflect the risk of relapse and death in children with this disease.

March 14, 2016
Cancer Cell

TARGET researchers performed genomic characterization of extra-cranial malignant rhabdoid tumors and found dysregulation of neural crest development genes.

March 03, 2016
Cancer Research

Researchers used whole exome capture sequencing to compare biopsies from the same patient at diagnosis, remission and relapse, revealing that there is significant variability between these stages.

December 04, 2015
Nature Communications

Researchers discover mutations in the MLLT1 gene in Wilms tumor that may help explain Wilms tumor development.

November 11, 2015

Investigators study the DNA variant in the LMO1 gene with leads to neuroblastoma development.

July 13, 2015

The authors analyzed a discovery set of 13 CCSKs for changes in chromosome copy number, mutations, rearrangements, global gene expression and global DNA methylation.

June 29, 2015
Nature Genetics

The authors provide a rationale for genetic characterization of relapse neuroblastomas.

March 19, 2015
Nature Communcations

Researchers use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymplobastic leukaemias from diagnosis to relapse.

February 09, 2015
Cancer Cell

Researchers report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors occur within SIX1/2, and microRNA processing genes DGCR8 and DROSHA.