TARGET investigators report on the key role that loss of TP53 plays in the development of anaplasia in Wilms tumors and may reflect the risk of relapse and death in children with this disease.
TARGET researchers performed genomic characterization of extra-cranial malignant rhabdoid tumors and found dysregulation of neural crest development genes.
Researchers used whole exome capture sequencing to compare biopsies from the same patient at diagnosis, remission and relapse, revealing that there is significant variability between these stages.
Researchers discover mutations in the MLLT1 gene in Wilms tumor that may help explain Wilms tumor development.
Investigators study the DNA variant in the LMO1 gene with leads to neuroblastoma development.
The authors analyzed a discovery set of 13 CCSKs for changes in chromosome copy number, mutations, rearrangements, global gene expression and global DNA methylation.
The authors provide a rationale for genetic characterization of relapse neuroblastomas.
Researchers use deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymplobastic leukaemias from diagnosis to relapse.
Researchers report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors occur within SIX1/2, and microRNA processing genes DGCR8 and DROSHA.