33 Publications Available
May 27, 2017

Investigators examined whether circulating miRNAs can be used as prognostic biomarkers in osteosarcoma patients. miR-21, miR-221, and miR-106a were found to be expressed significantly higher in cancer samples and were correlated with outcome.  

November 15, 2016
Clinical Cancer Research

Researchers from Children's Oncology Group reported on the key role that loss of TP53 plays in the development of anaplasia in Wilms tumors which might reflect the risk of relapse and death in children with this disease.

June 16, 2016

TARGET researchers performed comprehensive genomic analysis on 186 cases of pediatric AML with samples from marrow or peripheral blood and identified oncogenic colony-stimulating factor 3 receptor (CSF3R) mutations as a distinct molecular subtype of pediatric AML.

April 15, 2016
Cancer Research

This study used whole exome capture sequencing to compare biopsies from the same patient at diagnosis, remission and relapse and revealed that there was significant variability between these stages.

March 14, 2016
Cancer Cell

Investigators performed genomic characterization of extra-cranial malignant rhabdoid tumors and found dysregulation of neural crest development genes.

December 17, 2015

Scientists studied the DNA variant in the LMO1 gene which leads to neuroblastoma development.

December 04, 2015
Nature Communications

Researchers discovered mutations in the MLLT1 gene in Wilms tumor that might help explain Wilms tumor development.

August 01, 2015
Nature Genetics

Whole-genome sequencing showed high frequency of mutations that were predicted to activate the RAS-MAPK pathway in relapse neuroblastoma samples as well as in neuroblastoma cell lines.

June 30, 2015

The authors analyzed a discovery set of 13 CCSKs for changes in chromosome copy number, mutations, rearrangements, global gene expression and global DNA methylation.The study reported significant hypermethylation of TCF21 and/or decreased TARID expression in the cases of most CCSKs.

March 19, 2015
Nature Communcations

Researchers used deep whole-exome sequencing to describe the clonal architecture and evolution of 20 pediatric B-acute lymplobastic leukaemias from diagnosis to relapse.