Publications

35 Publications Available
December 02, 2010
Blood

Through unsupervised clustering of gene expression profiling, TARGET researchers discovered eight unique cluster groups among patients with pediatric high-risk B-precursor acute lymphoblastic leukemia (ALL). 

May 20, 2010
Journal of Clinical Oncology

Leaders from the NCI Cancer Therapy Evaluation Program (CTEP) and the Children’s Oncology Group provided an overview of the most current childhood cancer statistics. 

February 18, 2010
Blood

TARGET researchers used gene expression profiling to improve their ability to predict the outcome of children with high-risk B-precursor acute lymphoblastic leukemia (ALL).

June 09, 2009
Proceedings of the National Academy of Sciences

Researchers identified a poor prognostic subgroup of pediatric BCR-ABL1-negative ALL patients and reported that the JAK-mutated cases had a gene expression signature similar to BCR-ABL1 pediatric ALL and suggested inhibition of JAK signaling as a target for therapeutic intervention.

January 29, 2009
The New England Journal of Medicine

Scientists identified more than 50 recurring copy-number abnormalities in a cohort of patients with B-cell progenitor ALL. Abnormalities were found in genes that encode regulators of B-cell development, PAX5 and IKZF1, a gene that encodes the lymphoid transcription factor IKAROS.

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