All Resources

AIDS-Related Cancers

Find comprehensive information on HIV-associated cancers, including treatment, prevention, clinical trials, and more.

Burkitt Lymphoma Genome Sequencing Project (BLGSP) SOP Manual

Cancer Genome Anatomy Project (CGAP)

CGAP generated a wide range of genomics data on cancerous cells that are accessible through easy-to-use online tools. Researchers, educators, and students can find "in silico" answers to biological questions through the CGAP website. Request a free copy of the CGAP Website Virtual Tour CD from ocg@mail.nih.gov to learn how to navigate the website.

Cancer Genome Anatomy Project SNP500Cancer Database

Part of CGAP, the goal of the SNP500Cancer project is to resequence 102 reference samples to find known or newly discovered single nucleotide polymorphisms (SNPs) which are of immediate importance to molecular epidemiology studies in cancer.

Cancer in Children and Adolescents

View a fact sheet that has statistics as well as information about types, causes, and treatments of cancers in children and adolescents in the United States. 

https://www.cancer.gov/types/childhood-cancers/child-adolescent-cancers-fact-sheet

Cancer Therapy Evaluation Program

The Cancer Therapy Evaluation Program (CTEP) seeks to improve the lives of cancer patients by finding better treatments, control mechanisms, and cures for cancer. CTEP funds a national program of cancer research, sponsoring clinical trials to evaluate new anti-cancer agents.

Center for Cancer Genomics

The Center for Cancer Genomics (CCG) was established to unify the National Cancer Institute's activities in cancer genomics, with the goal of advancing genomics research and translating findings into the clinic to improve the precise diagnosis and treatment of cancers. In addition to promoting genomic sequencing approaches, CCG aims to accelerate structural, functional and computational research to explore cancer mechanisms, discover new cancer targets, and develop new therapeutics. The Office of Cancer Genomics and The Cancer Genome Atlas Program Office are the CCG member offices that work to achieve the center’s mission.

 

Chembank

Funded in large part by the Initiative for Chemical Genetics (ICG), Chembank is an interactive database for small molecules. It contains data from hundreds of biomedically relevant small molecule screens that involved hundreds-of-thousands of compounds. Chembank also provides analysis tools to facilitate data mining.

Childhood Cancers

Find comprehensive information on childhood cancers: current treatments, clinical trials, prevention, genetics, testing, and more.

Childhood Cancers in Spanish (Español)

Cáncer infantile

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRi) plasmids

CTD2 researchers at the University of California in San Francisco developed a modified Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) CRISPR/dCas9 system. Catalytically inactive dCas9 enables modular and programmable RNA-guided genome regulation in eukaryotes. The CRISPR/dCas9 system has several advantages:  i) enables robust gene repression (CRISPRi) or activation (CRISPRa) in human cells, ii) allows specific knockdown with minimal off-target effects in human cells, iii) works efficiently in human and yeast cells, and iv) does not cause  double-strand breaks. Plasmid design and construction for CRISPRi (human and yeast cells) are described in the manuscript listed below and are available through a distributor.

www.addgene.org/crispr/qi-weissman/ 

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS (2013). CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes. Cell 154(2):422-51. PMID: 23849981

Genome-wide Association Studies from the Cancer Genetic Markers of Susceptibility (CGEMS) Initiative

CGEMS identifies common inherited genetic variations associated with a number of cancers, including breast and prostate. Data from these genome-wide association studies (GWAS) are available through the Division of Cancer Epidemiology & Genetics website.

Guide to Accessing Program Data

Visit the Guide to Accessing Data page for a visual and interactive guide on how to access OCG program data. 

HIV+ Tumor Molecular Characterization Project (HTMCP) SOP Manual

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Human cDNA Library from the ORFeome Collaboration (OC)

The goal of the OC, an informal volunteer multi-institutional collaboration, is to provide the research community with validated, full open reading frame (ORF) cDNA clones for all of the currently defined human genes.  The ORF clones do not include 5’ and 3’ UTRs and can be easily sub-cloned into any type of expression vector. These clones are available to researchers worldwide through multiple distributors.

Informed Consent Template

Mammalian cDNA Library from the NIH Mammalian Gene Collection (MGC)

The MGC provides the research community full-length clones for most of the defined (as of 2006) human and mouse genes, along with selected clones of cow and rat genes. Clones were designed to allow easy transfer of the ORF sequences into nearly any type of expression vector. MGC provides protein ‘expression-ready’ clones for each of the included human genes. MGC is part of the ORFeome Collaboration (OC).

National Cancer Institute

Visit the NCI website for comprehensive cancer information.

NCI’s Lung Cancer page

Learn an abundance of current information on lung cancer.

NCI’s Non-Hodgkin Lymphoma page

Find comprehensive information on NHL, including testing, treatment, genetics, clinical trials, and more.

Office of HIV and AIDS Malignancies (OHAM)

NCI’s Office of HIV and AIDS Malignancies (OHAM) is a great resource for learning about HIV-associated cancers.

Online Bioinformatics Tutorials

Bioinformatics is a scientific discipline that applies computer science and information technology to help understand biological processes. The NIH provides a list of free online bioinformatics tutorials, either generated by the NIH Library or other institutes, which includes introductory lectures and "how to" videos on using various tools.

Open versus Controlled-Access Data

OCG employs stringent human subjects’ protection and data access policies to protect the privacy and confidentiality of the research participants. Depending on the risk of patient identification, OCG programs data are available to the scientific community in two tiers: open or controlled access. Both types of data can be accessed through its corresponding OCG program-specific data matrix or portal.

Open-access Data

Data within this category presents minimal risk of participant identification. Much of OCG program data, excluding patient identifiers, are open-access. OCG provides the scientific community the maximum amount of open-access data allowable under HIPAA guidelines. Access to these data does not require user certification, and researchers may explore data content without restriction.

Controlled-access Data

Data within this category present a higher risk of patient identification. While stripped of direct patient identifiers as defined by HIPAA, controlled-access data contain specific demographic, clinical, and genotypic information that are excluded in open-access data. Controlled-access data are unique and valuable to research projects for which open-access data are insufficient. Access to protected data requires user certification which can be obtained through NCBI’s dbGaP (National Center for Biotechnology Information’s database of Genotypes and Phenotypes). 

To learn more and understand which data each OCG program provides, visit How to Access Multiple Datasets

Protein-Protein Interaction Reagents

The CTD2 Center at Emory University has a library of genes used to study protein-protein interactions in mammalian cells. These genes are cloned in different mammalian expression vectors. A list of available cancer-associated genes can be accessed below.

FileEmory_CTD^2_PPI_Reagents.xlsx

Contact: Haian Fu 

TARGET Project Experimental Methods

On this page researchers can find detailed information describing how TARGET data was generated by genomic platform, including protocols for establishing high-quality nucleic acid samples.

The Cancer Genome Atlas (TCGA) Data Portal

The Cancer Genome Atlas Data Portal contains clinical information, genomic characterization data, and high-throughput sequencing analysis of over twenty different cancers. Search, download, and analyze data sets generated by TCGA.

What is Cancer?

A brief explanation of how cancer forms, basic statistics, and links to additional resources.