OCG Templates and Protocols

The OCG Standard Operating Protocols (SOPs) and templates are guidelines for investigators participating in OCG programs such as CGCI's Burkitt Lymphoma Genome Sequencing Project (BLGSP), and HIV+ Tumor Molecular Characterization Project (HTMCP), the Human Cancer Models Initiative (HCMI), and Therapeutically Applicable Research To Generate Effective Treatments (TARGET). Investigators must follow the protocols in the SOPs when contributing samples and data. The sample and data acquisition process is explained in comprehensive detail to ensure that all materials and data will be of sufficient quality. Depending on the role in the acquisition process, only a certain number of protocols may apply to a particular investigator. Should you require any clarification, please contact the appropriate OCG personnel listed in the SOP.

Burkitt Lymphoma Genome Sequencing Project (BLGSP) Standard Operating Procedures (SOP) Manual

CDE (Common Data Element) Browser User Guide

HCMI Case Report Forms (CRFs)

Human Cancer Models Initiative's cancer type-specific CRFs have been developed through collaborations with international clinical experts and the clinical data elements have been standardized through the Cancer Data Standards Registry and Repository (caDSR). Enrollment and Follow-up CRFs are available below for download. As the tumor types modeled through the HCMI are constantly updated, be sure to check back regularly for additional or updated CRFs. Note: In some cases, it is possible to generate more than one distinct model from primary, metastatic, and/or recurrent tumor tissues per participant. New CRFs capture information about multiple models developed from the same participant within a single form. The multiple model CRFs are designated with "-multi" within the file name. Versioning is used if there are any subsequent edits to the CRFs. 

HCMI Searchable Catalog

HCMI Searchable Catalog is a continuously updated resource for querying the available next-generation models developed by HCMI. Within the catalog, users can search by patient demographics, tumor, and model elements including age at diagnosis, sex, treatment information, clinical tumor diagnosis, primary site, clinical stage, and type of model (e.g. 3D-organoid, 2D-conditionally reprogrammed cells), etc. For additional assistance in navigating the searchable catalog, please see the “HCMI Searchable Catalog User Guide”. 

HCMI Searchable Catalog 

HCMI Searchable Catalog User Guide

This guide provides users with a resource to effectively navigate the HCMI Searchable Catalog.

HCMI Searchable Catalog User Guide

HIV+ Tumor Molecular Characterization Project (HTMCP) Standard Operating Procedures (SOP) Manual

Informed Consent Template for Tissue Accrual to Enable Model Development and Distribution

Successful Standard Operating Procedures (SOPs)

Standard Operating Procedures (SOPs) are written instructions for doing a specific task in a certain way (Source: NCI).  The purpose of an SOP is to guide a novice to carry out a particular task in an accurate and consistent manner.

Download: PDF iconCharacteristics_of_Successful_SOPs.pdf

TARGET Project Experimental Methods

On this page researchers can find detailed information describing how TARGET data was generated by genomic platform, including protocols for establishing high-quality nucleic acid samples.